Democratizing Molecular Biology

Moving complex molecular analytics to the point-of-need

We are simplifying complex molecular techniques, moving them out of highly-skilled labs to non-laboratory settings where they can be used at the point-of-need to solve biological problems.

This is democratizing molecular biology.

The first step is rapid nucleic acid extraction, enabling efficient sample preparation with minimal intervention. Whether it’s a farmer’s field in Uganda to diagnose cassava mosaic virus or the depths of the Pacific Ocean to sample and analyze water pathogens, we are putting rapid extraction capabilities in the places they are needed.

Today, we are integrating our foundational expertise in microfluidics and nucleic acid extraction into a simple and elegant sample-to-result molecular diagnostic platform, creating the next generation of point-of-need solutions.

We’re pitching in to do our part to fight the COVID-19 pandemic, expediting the development of our molecular diagnostic test to identify SARS-CoV-2 and influenza types A and B at the point of need.

Researchers at the Monterey Bay Aquarium Research Institute (MBARI) are protecting our oceans with their Environmental Sample Processor, an autonomous molecular analytical laboratory. The underwater robot fully automates remote sample collection and provides real-time analysis of water quality and pathogens. MicroGEM’s RNAGEM is part of the solution, providing minimal sample manipulation and rapid RNA extraction. MBARI’s work is reshaping the way we monitor our environment to protect its health now and for future generations.

Optimizing speed, sample size,
and simplified workflows

Our enzymatic approach sets the standard for DNA and RNA extraction. Single-tube protocols isolate and stabilize nucleic acids in minutes – not hours – without harsh chemicals or multiple steps. Reduced handling means fewer opportunities for contamination and errors, all saving time and money.

MicroGEM’s enzymatic DNA extractions, driven by temperature changes in a single tube, effectively lyse nucleic acids from a very small number of cells, making this an ideal process for applications with low abundance transcripts and small sample volumes.

Find your sample, discover your solution.

Click on your sample type to learn more about our extraction reagents and incorporating them into your workflow.

Bacteria

Gram-positive, Gram-negative, protozoa, colonies and liquid cultures, biofilm and mucosal, archaea, swabs, and metagenomic DNA (soil, stool, and water)

Plant

Plant (leaf, stem, root), plant pathogens, fungi

Cell Culture

Extract DNA from cells in suspension, adhered cells, cell pellets, VACS, and LCM

Sperm

Extract DNA from sperm cells, semen, semen stains, and vaginal swabs

RNA

Extract RNA from mammalian cell culture, laser capture micro-dissections, FACS-prepared cell populations such as macrophages

Extract DNA from liquid blood (fresh, EDTA, heparin, citrate), swab, stains, storage card (FTA)

Extract DNA from animal tissue including insect, mouse and rat tail tips, fish fins, ear tags, fat, muscle, tape lifts, hair

Extract DNA from liquid saliva, swab, stains, storage card (FTA)

prepGEM Bacteria effortlessly extracts DNA from a wide variety of microbial samples including Gram positive and negative bacteria, protozoa, archaea, and metagenomic DNA from soil, stool, or water samples.

MicroGEM’s transformative approach to sample preparation: temperature-driven, enzymatic nucleic acid extraction.

Our single-tube approach removes the need for multiple steps and harsh chemicals needed for conventional extraction methods.

Our thermostable proteinase functions at temperatures perfect for nucleic acid extraction – inactive at low temperatures, turning on at 75°C and irreversibly denaturing at 95°C.

No detergents. No denaturants. No complex steps. Only heat.

That’s temperature-driven nucleic acid extraction done effortlessly.

More about MicroGEM’s approach.

Champagne Pool, Rotorua, New Zealand - an example of an extreme environment that contributes to MicroGEM's one-of-a-kind culture collection.
Champagne Pool, Rotorua, New Zealand

We’ve tapped into the power of extremophiles that thrive in the world’s most extreme conditions.

We use enzymes derived from these microorganisms to quickly and simply extract nucleic acid from many sample types. Temperature-driven enzymatic lysis offers significant advantages.

More about MicroGEM’s one-of-a-kind culture collection.

David Saul of MicroGEM during his exploration of Mt. Erebus in Antarctica. Circa 2002.
Dr. David Saul: scientist, explorer, inventor, founder.

Our company is like our culture collection: diverse and strong.

At MicroGEM, we’re explorers and innovators, pushing the boundaries of efficient sample preparation and rapid point-of-need diagnostics.

More about MicroGEM.