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Democratizing Molecular Biology

Transforming complex molecular biology techniques into simplified workflows.

No harsh chemicals. No denaturants. No complex steps.

Temperature-driven DNA and RNA extractions: Optimizing speed, sample size, yield, and single-tube processing.

Find your sample, discover your solution.

Click on your sample type to learn more about temperature-driven reagents and incorporating them in your lab’s workflow.


Gram-positive, Gram-negative, protozoa, colonies and liquid cultures, biofilm and mucosal, archaea, swabs, and metagenomic DNA (soil, stool, and water)


Plant (leaf, stem, root), plant pathogens, fungi

Cell Culture

Extract DNA from cells in suspension, adhered cells, cell pellets, VACS, and LCM


Extract DNA from sperm cells, semen, semen stains, and vaginal swabs


Extract RNA from mammalian cell culture, laser capture micro-dissections, FACS-prepared cell populations such as macrophages

Extract DNA from liquid blood (fresh, EDTA, heparin, citrate), swab, stains, storage card (FTA)

Extract DNA from animal tissue including insect, mouse and rat tail tips, fish fins, ear tags, fat, muscle, tape lifts, hair

Extract DNA from liquid saliva, swab, stains, storage card (FTA)

Are you looking for a rapid, efficient RNA extraction solution? Check out our RNAGEM Technical Product Review or visit

Download our brochure to see how simple nucleic acid extractions can be.

Download our product guide for a comprehensive overview of our kits, instruments, and accessories.

We have discovered how to simplify life science research by reinventing the way nucleic acids are extracted. Using novel chemistries, we’ve enabled samples to be molecular-biology ready in one easy step using single-tube DNA/RNA extraction.

David Saul, PhD
Chief Scientific Officer

Our temperature-driven approach sets the standard for DNA and RNA extractions where speed, sample size, yield, and simplified workflow are important. Single-tube extractions produce high-quality nucleic acids in minutes – not hours – without the overuse of plastic or harsh chemicals. Reduced handling means fewer opportunities for contamination, all at an affordable cost.

Whether you’re a life scientist or forensic specialist, you’ll find the solution that suits your needs:

  • Transfected Cell Screening
  • FACS Sorted Cells
  • Whole Genome Sequencing
  • STR
  • PCR
  • qPCR
  • RT-PCR
  • Y-Screening
  • Differential Extractions
  • Human ID

Compare MicroGEM’s single-tube approach to the multiple steps of conventional approaches

prepGEM Bacteria effortlessly extracts DNA from a wide variety of microbial samples including Gram positive and negative bacteria, protozoa, archaea, and metagenomic DNA from soil, stool, or water samples.

MicroGEM’s transformative approach to effortless sample preparation: temperature-driven nucleic acid extraction.

We’ve invested decades of scientific discovery and validation to create simplicity from complexity. Our single-tube approach removes the need for multiple steps and harsh chemicals needed for traditional extraction methods.

Our thermostable proteinase functions at temperatures perfect for nucleic acid extraction – inactive at low temperatures, turning on at 75°C and irreversibly denaturing at 95°C.

No detergents. No denaturants. No complex steps. Only heat.

That’s temperature-driven nucleic acid extraction done effortlessly.

More about MicroGEM’s approach.

The PDQeX Nucleic Acid Extractor simplifies molecular biology workflows.

MicroGEM’s PDQeX Nucleic Acid Extractor performs temperature-driven extractions on a wide variety of sample types.

MicroGEM offers sophisticated simplicity in the PDQeX Nucleic Acid Extractor – our automated solution for effortless DNA or RNA extraction.  Powerful enzyme-driven reagents and an innovative extraction cartridge produce analytics-ready nucleic acids in less than 15 minutes.

  • Optimized for cell lysis and purification
  • Simplified workflow in a single closed-tube system to handle challenging samples
  • Perfect for labs looking for fast, simple sample processing

More about MicroGEM’s automated solution.

Champagne Pool, Rotorua, New Zealand - an example of an extreme environment that contributes to MicroGEM's one-of-a-kind culture collection.
Champagne Pool, Rotorua, New Zealand

We’ve gone to extremes for effortless nucleic acid extraction.

We’ve tapped into the power of extremophiles that thrive in the world’s most extreme conditions.

We use enzymes derived from these microorganisms to quickly and simply extract nucleic acid from many sample types. Temperature-driven enzymatic lysis offers significant advantages.

More about MicroGEM’s one-of-a-kind culture collection.

David Saul of MicroGEM during his exploration of Mt. Erebus in Antarctica. Circa 2002.
Dr. David Saul: scientist, explorer, inventor, ZyGEM founder.

Our company is like our culture collection: diverse, strong, and unconventional.

At MicroGEM, we’re explorers and innovators, pushing the boundaries of effortless sample preparation and nucleic acid extraction.

More about MicroGEM.